Bioprospecting Antiproliferative Marine Microbiota From Submarine Volcano Tagoro

Marine ecosystems are unique and rich reservoirs of biodiversity with high potential toward improving the quality human life. The extreme physical–chemical conditions oceans have favored marine organisms to produce a great variety new molecules as mechanism ensure their survival, such compounds possess biopharmaceutical interest. In particular, microbiota represent promising inexhaustible source for development drugs. This work presents taxonomic study samples obtained from underwater volcano Tagoro, which has allowed us develop collection 182 bacterial strains. On October 10th, 2011, at La Restinga–El Mar de Las Calmas Reserve, an eruption gave rise novel shallow submarine 1.8 km south island El Hierro, Canary Islands, Spain. During first 6 months, perturbations, comprising thermal changes, water acidification, deoxygenation, metal enrichment, resulted in significant alterations ecosystem. After March 2012, Tagoro entered active hydrothermal phase that involved release heat, gases, metals, micronutrients continues till our present. 2016, research team had opportunity participate one monitoring oceanographic cruises carried out area order isolate microorganisms associated both rock deep-sea invertebrates over volcano. this study, Proteobacteria revealed most abundant Phylum 70.2% among all isolated strains, followed by Firmicutes 19%, Actinobacteria 9.5%, Bacteroidetes 1.2%. Furthermore, we present results antiproliferative assays extracts small-scale cultures selected An analysis effects culture activity showed strains grown Broth (MB) presented lower GI 50 values than those cultured modified medium (MM1). effect is improved when incubated under agitation conditions. genera Halobacillus , Kangiella Photobacterium Halomonas revealed. Their biotechnological provides excellent starting point access secondary metabolites enzymes pharmaceutical industrial applications.